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In 2007, Wilde was a part of the ensemble cast of the shortly lived NBC midseason drama The Black Donnellys. Her character, Jenny Reilly, was the lone principal female character in the series following the lives of an Irish-American family tied to organized crime in New York City. Also in 2007, Wilde appeared in the play Beauty on the Vine, a political thriller, playing three different characters.
Wilde joined the cast of the FOX medical drama House in fall 2007, playing a young doctor nicknamed Thirteen who will work closely with Dr. House. According to E!, she has signed on as a regular on the show.
The New York Observer has described Wilde as having a “throaty voice” and the “wide, teal-eyed charisma of Hollywood in the days of yore”. She has cited Meryl Streep, Sigourney Weaver, Frances McDormand, Catherine Keener and Robin Wright Penn as acting inspirations, and also admires playwright Eve Ensler and director and actor Woody Allen. [Wiki]